β-Caryophyllene – Terpen Profil

In der Natur gibt es 3 Isomere (α-, β- und γ-Caryophyllen), wobei β-Caryophyllen das am häufigsten anzutreffende und am häufigsten vorkommende der Isomere ist.

Zu finden in:
Dieses Sesquiterpen kommt am häufigsten in Nelken, schwarzem Pfeffer, Basilikum, Oregano und Cannabis vor. Zeichnet sich durch seinen würzigen und pfeffrigen Geruch aus.

Therapeutische Eigenschaften:
Darüber hinaus wird als herausragendes Merkmal angenommen, dass β-Caryophyllen an CB2-Rezeptoren bindet und das Endocannabinoid-System aktiviert. Die β-Caryophyllen-Dosis erzeugt keine psychoaktive Wirkung.

Gefunden in:
Schwarzer Pfeffer

Siedepunkt:
130 ℃
266 ℉

In vivo Anti-anxiety
- β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice/
- The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice/ β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice

Anti-Cancer
- Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells/
- β-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines/
- Antimicrobial activity of terpenoids from Copaifera langsdorffii Desf. against cariogenic bacteria /
- Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel/ β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties

Anti-inflammatory 
- Investigation of the anti-inflammatory and analgesic activities of β-caryophyllene/ 
- β-Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats/ 
- Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea/ 
- Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene/ 
- Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

Prevent Alzheimer's Disease
- PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease

In vivo Prevent Diabetes
- β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats

Antinociception
- Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception

In vivo Increase Longevity And Mitochondrial Function
- Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway/
- β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn/
- Local anaesthetic activity of beta-caryophyllene

In vivo Protects Kidney
- β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner

In vivo Relieves Pain
- Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception

In vitro Antispasmodic - Ileum
- Antispasmodic effects of essential oil of Pterodon polygalaeflorus and its main constituent β-caryophyllene on rat isolated ileum

Skin Repair
- Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells

Skin Absorption
- Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method